prevalence of congenital hypothyroidism and transient increased levels of tsh in yazd province

Authors

محمود نوری شادکام

m noori shadkam مجید جعفریزاده

m jafarizadeh محسن میرزایی

m mirzaei محمد اسماعیل مطلق

me motlagh ضیاء اسلامی

abstract

introduction: congenital hypothyroidism is one of the most preventable causes of mental retardation. worldwide, incidences vary from 1:3000 to 1:4000 and mean incidence in iran is estimated to be 1:1000. neonatal screening and early treatment within first 2 weeks of neonatal period can prevent neurocognitive deficits. we aimed to study the incidence of ch and increased levels of tsh in yazd province and collect data describing the disease status and designing first and second levels of preventive interventions. methods: this descriptive analytic study was performed by census cross sectional method on 13022 neonates in yazd province in 2006-2007(march 2006- march 2007) including 6495 females and 6527 males. sampling was done (within the first 3-5 days of life) by lancet sticking of neonatal heel. after transfer of 3 blood drops over filter papers, the tsh level was measured. if the tsh level was equal or higher than 5 mu/l, additional confirmation tests were done. neonates were diagnosed according to serum confirmation test (tsh10 mu/l or t4<6.5g/dl) and underwent treatment according to national guidelines. data was analyzed by spss software. results: total number of patients was 45, including 25 males (55.5%) and 20 females (44.5%). prevalence in males, females and overall was consecutively, 1:261, 1:325 and 1:289, but this difference was not statistically significant. prevalence in urban and rural areas was 1:315 and 1:216, but the difference was statistically not significant. the prevalence during spring, summer, autumn& winter was 1:95, 1:250, 1:1934 and 1:369, respectively, that was statistically significant. mean age at sampling was 7.2 days, mean tsh level 2.3 mu/l and mean age of mothers was 25.8 years. conclusions: incidence of ch and transient increased levels of tsh in yazd province is significantly higher than national and worldwide levels that necessitate the constancy and reinforcement of neonatal screening program. on the other hand, complementary studies for recognizing relevant factors, particularly iodine deficiency are one of the priorities of health system research in yazd.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Congenital Hypothyroidism: Increased Incidence in Yazd Province, Iran

Introduction: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation. Its worldwide incidence is estimated to be one in 2500-5500 births. Assessment of thyroid gland in neonates is critical. The aims of this study were to demonstrate the incidence of CH in neonates born in Yazd province, Iran in 1389 (2010) and compare the results with other reported s...

full text

The Prevalence of Transient and Permanent Congenital Hypothyroidism in Infants of Kurdistan Province, Iran (2006-2014)

Background: Congenital hypothyroidism (CH) is the most common endocrine diseases and one of the major causes of preventable mental retardation. This study was conducted to investigate the prevalence of transient and permanent congenital hypothyroidism in Kurdistan province, Iran.Materials and Methods: In this cross-sectional study, all registered congenital hypothyroidism neonate of health cent...

full text

congenital hypothyroidism: increased incidence in yazd province, iran

introduction: congenital hypothyroidism (ch) is one of the most common preventable causes of mental retardation. its worldwide incidence is estimated to be one in 2500-5500 births. assessment of thyroid gland in neonates is critical. the aims of this study were to demonstrate the incidence of ch in neonates born in yazd province, iran in 1389 (2010) and compare the results with other reported s...

full text

the prevalence of transient and permanent congenital hypothyroidism in infants of kurdistan province, iran (2006-2014)

background: congenital hypothyroidism (ch) is the most common endocrine diseases and one of the major causes of preventable mental retardation. this study was conducted to investigate the prevalence of transient and permanent congenital hypothyroidism in kurdistan province, iran.materials and methods: in this cross-sectional study, all registered congenital hypothyroidism neonate of health cent...

full text

morphology, geochemistry, mineralogy, and micromorphology of soils of hormozgan province in relation to parent materials

ویژگی های زمین شیمیایی، کانی شناسی، و میکرومورفولوژیکی خاک ها و سنگ مادر مربوطه در منطقه بین بخش های جنوبی زاگرس و خلیج فارس تا دریای عمان(استان هرمزگان، ایران) مورد بررسی قرار گرفت. هدف های این مطالعه شناسایی تغییرات در خصوصیات فیزیکی، شیمیایی، و ترکیب کانی شناسی خاک، مطالعه میکرومورفولوژی و تکامل خاک، و بررسی توزیع عنصر خاک بر اساس هوازدگی، پروسه های خاک و زمین شناسی جهت توصیف اثرات مواد مادر...

15 صفحه اول

My Resources

Save resource for easier access later


Journal title:
مجله دانشگاه علوم پزشکی شهید صدوقی یزد

جلد ۱۶، شماره ۳، صفحات ۳۱۵-۳۱۵

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023